Holden and Banky are best friends and authors of a popular comic book called "Bluntman and Chronic" (based on Jay and Silent Bob of "Clerks" and "Mallrats" fame). Holden falls in love with Alyssa, also a comic book artist, who happens to be a lesbian. Holden's new relationship with Alyssa strains his life-long friendship with Banky, and soon the relationship between Holden and Alyssa hits a wall due to Holden not being able to deal with her past.

This is the third film in Kevin Smith's intricately interconnected View Askewniverse series (the others being Clerks, Mallrats, Dogma and Jay and Silent Bob Strike Back). The movies are all linked by characters, themes and events and each contains numerous references to the others.

Silent Bob tells Jay that "What he doesn't know about him could just about fill the Grand Canyon". In Butch Cassidy and the Sundance Kid Robert Redford says the same thing to Paul Newman.

Holden and Banky are both characters in J. D. Salinger's novel, "The Catcher in the Rye". (In the novel, "Ed Banky" was a gym teacher who would let students borrow his car so they could make out and have sex with their girlfriends.)

The sign for the Manhattan Comiccon notes that the event is presented by "Flanagan Events". This is a reference to Walter Flanagan, who played several roles in both Clerks and Mallrats. He was supposed to be in Chasing Amy as Walt the fan boy, but his scenes were deleted.

Banky's comic "Baby Dave" is a reference to David Klein, director of photography for Clerks, Mallrats, and Chasing Amy.

The Button on Hooper's jacket during the "black rage" scene says "The Black Man is God." It was found and suggested by the actor, Dwight Ewell.

When Holden and Alyssa go skee-balling, there is a coin machine with the name "Gottlieb" on it (a major arcade-game maker). Carl Gottlieb was the co-writer of the Jaws screenplay, favorite film of director Kevin Smith.

Carmen Lee who played Kim, Alyssa's lesbian lover, was the wife of star Jason Lee. Joey Lauren Adams who played Alyssa was director Kevin Smith's girlfriend.

During the scene where Holden and Alyssa are playing darts, men are going in and out of the women's bathroom and women are going in and out of the men's bathroom.

The scene between Alyssa, Holden and Banky at the nightclub discussing problems with oral sex was originally written for Mallrats, between T.S., Brodie, and Gwen.

Holden says he attended a school named Hudson - which is the real school that Kevin Smith and Jason Mewes both graduated from.

Kevin Smith wrote the script to Chasing Amy inspired by his experience with then girlfriend Joey Lauren Adams.

Joey Lauren Adams wrote the song she sings. It was originally a country song but Kevin Smith requested they pump it up a bit.

Kevin smith wrote the three issues of the "Bluntman and Chronic" comic book that Holden and Banky produce with in the film, and them released through Image Comics. Inside each issue, Smith credited: Written by Banky Edwards and Holden McNeil, Pencils by Holden McNeil, Inks by Banky Edwards.

Director Trademark: The sequence in the club, where Banky and Alyssa compare cunnilingus scars and stories, parodies a similar scene on board the boat in Jaws between Hooper and Quint.

Director Trademark: During Hooper's convention speech about racism in science fiction, Star Wars and its sequels are discussed.

Director Trademark: Holden and Alyssa break up at a hockey game. Alyssa is wearing a Toronto Maple Leafs jersey.

Director Trademark: The main characters are all comic book creators.

Director Trademark: Several of the opening credits news clippings have references to the number 37.

When Smith pitched the idea to Miramax films, he also said that he had written the parts with his friends, Ben Affleck, Jason Lee, and Joey Lauren Adams, in mind. Miramax, however, wanted to cast people who already had celebrity status, such as Jon Stewart, David Schwimmer, and Drew Barrymore (these three were actually suggested). The film's original budget of $3,000,000 depended on Miramax's support. Ultimately, Smith suggested that he make the movie with his three original actors on his own, and Miramax could buy it for distribution if they liked it. The brothers Weinstein liked this idea, and gave him $250,000 to make the movie (1/24 of the budget of his previous film, Mallrats).

Silent Bob (despite his name) has one of the longest speeches in the movie.

Banky and Holden's studio in Red Bank, New Jersey is called 'Bank-Hold-Up".

Crew or equipment visible: Camera operator visible in a reflection in a window while Holden is walking back to his car in the rain.

Continuity error: During the hockey fight #12's helmet is off, then on, then off again.

Continuity error: Ally's hair during her long monologue in the couch after making love with Holden. She has it back her ear, then on her cheek, then on the ear again.

Continuity error: Cigarette ash on Holden's pant leg when in the diner with Jay and Silent Bob.

Continuity error: The length of Silent Bob's cigarette when giving the speech about the origins of "Chasing Amy".

Continuity error: Silent Bob throws the comic magazine on the table twice times while he and Jay are in the diner with Holden talking about "Chasing Amy".

Crew or equipment visible: Holden's radio mike is visible under his shirt in the CD store when he's talking to Hooper.

Continuity error: The scene with Holden and Alyssa is shot on a two-way street from inside the car, but a one way street when they get out of the car. Also, they are going the wrong way on that street (just before they get back into the car a street sign is visible over the roof of the car).

Revealing mistake: When Holden and Alyssa are driving back with art work the speedometer does not move.

Revealing mistake: Hooper-X is asked to sign the little boy's comic book at the record store, and as the boy walks away, the comic book is seen to be an Avengers comic (the advertisement on the back indicates that it is from the early-to-mid '80s).

Revealing mistake: While Holden and Alyssa argue in the rain, they are standing in front of an alley where it is clearly not raining.

Continuity error: When Holden and Banky are in the office with the executives, Exec. #1 isn't wearing a watch, but can be seen later on in this scene, where we can see a watch on his left wrist.

Continuity error: When Banky is signing the last copy of "Bluntman and Chronic", the sharpie is in his left hand one minute and his right the next.

Many things cut from the final version available on laserdisc/DVD editions:

Pre-credits scene in Comic Toast (the comic store from Mallrats), where Bryan Johnson and Walt Flanagan reprise their "Mallrats" roles as Steve-Dave and Walt the Fan-Boy respectively;

Longer rant by Hooper about black comic book characters;

A little bit more between Hooper and his older boyfriend (played by Bob Hawk);

A near-monologue by Alyssa about the true definition of love, during the darts scene;

A tag-on to the end of the dart scene, between Holden and Hooper;

Holden comes to Alyssa's apartment and gets confronted by one of her girlfriends, played by Illeana Douglas;

More development of the "selling out" subplot about the MTV series, including Holden and Banky's lawyer, John Sloss

Alyssa comes to their apartment while they're playing EA Hockey, and watchs Holden beat Banky easily;

In the skee-ball scene, Alyssa tells Holden that Banky is a passive-aggressive gay basher, partially for what he said in the EA Hockey scene;

Longer fight between Holden and Banky (before Holden is dating Alyssa);

More dialogue as Alyssa barters with the diner guy;

A little more in the scene between Alyssa and her lesbian friends as she tells them about Holden (some of this was shown in the trailers).

Edited for T.V. version seen on Oxygen channel has less offensive words overdubbed by the actors. Most notably all instances of the F-word are replaced with "humping"

In the trailers, the arcade scene where Alyssa says she got "laid" is replaced by her saying she got "lucky"

Hooper: For years in this industry, whenever an African American character, hero or villain, was introduced - usually by white artists and writers - they got slapped with racist names that singled them out as Negroes. Now, my book, "White-Hating Coon," don't have none of that bullshit. The hero's name is Maleekwa, and he's descended from the black tribe that established the first society on the planet, while all you European motherfuckers were hiding out in caves and shit, all terrified of the sun. He's a strong role model that a young black reader can look up to. Cause I'm here to tell you, the chickens is coming home to roost, y'all. The black man's no longer gonna play the minstrel in the realm of comics and sci-fi fantasy. We keepin it real, and we gonna get respect by any means necessary.

Holden: Ah, come on, that's a bunch of horse shit! Lando Calrissian was a black guy. You know, and he got to fly the Millennium Falcon, what's the matter with you?

Hooper: Who said that?

Holden: I did! Lando Calrissian is a strong role-model in the realm of science fiction/fantasy.

Hooper: Fuck Lando Calrissian! Uncle-Tom nigger!