A calamity at Dante and Randall's shops sends them looking for new horizons - but they ultimately settle at Mooby's, a fictional fast-food restaurant. Free from his dead-end job (and lodged in a new one), Dante begins to break free of his rut, planning to move away with his clingy fiancé. Dante is ready to leave the horrors of minimum-wage New Jersey behind, but Randal - always the more hostile of the two - starts to become overwhelmed by his own rancor.

Originally, a version of the script for this movie "became" parts of the film Jay and Silent Bob Strike Back (2001) and Kevin Smith said that that's the closest he'd come to a Clerks. (1994) sequel and that he was putting Jay and Silent Bob to rest. However, after working on the 10th anniversary edition DVD of the original "Clerks", Smith remembered how much he fell in love with the characters and why he got into the movie business in the first place, and decided to make this movie.

This movie is separate from the upcoming Clerks animated movie which is a "spin-off" of the short-lived ABC sitcom.

Kevin Smith auctioned off a walk on role on the film for funds to go to the Red Cross for aid to Hurricane Katrina victims. The final bid was $16,000 which Smith matched to give to the Red Cross

Although the other films Kevin Smith has made have all (with the exception of 'Jersey Girl been interlocked with recurring characters, locations, and themes as well as many references to each other, this is the first real "sequel" made to any of the films.

One of the things that most prompted Kevin Smith to make the film was a promise he made to friend Jason Mewes. If Mewes managed to stay off drugs he would be able to play the character of "Jay" one more time. Smith kept his promise.

The letters in the Clerks II logo all come from various fast food logos/products. The C from Carl Jr.'s, L from McDonald's Large fries, E from Burger King's Whopper, R from Burger King, K from KFC, and S from Popeye's.

Screened out of competition at the 2006 Cannes Film Festival and received an eight-minute standing ovation from the midnight crowd.

The shot of the cup scooping ice from a urinal was directed by Jason Mewes.

Joel Siegel, film critic for "Good Morning America", walked out 40 minutes into a screening of the film. In his own words: "First movie I've walked out of in 30 fucking years!". The straw that broke the camels back was the scene where two of the characters discuss hiring a woman to perform sex acts on a donkey.

Kevin Smith's daughter Harley Quinn is the little girl that Dante waves to in the window of the restaurant.

Emma's line to Dante - "Face it tiger. You just hit the jackpot" - is a (rather obscure) Spider-Man reference. This is the first line spoken by Mary Jane in the original comic.

Continuity Error: Dante's hair changes significantly when Becky sits down to talk to him about the wedding and dancing at the reception, and then again later throughout other scenes.

Error: The setting of the clerks movies is in New Jersey. Where the land is flat and lush and the only place that has palm trees is the coast. When Dante and Randall go go-carting, they seem to be in a desert with hills and palm trees. It is obvious that they are in California.