This movie sets up the series, Crusade, the sequel to Babylon 5.

John Sheridan: Those who command the Excalibur will never stop, never give up, never slow down, until a cure is found. We will take any help we can get, wherever and whoever it comes from. Because this is a cause that surpasses borders and differences and distrust. This is a mission about the survival of Earth itself. What we do over the next five years, here and at home, and across the darkness of between the stars will determine the whether an entire world will live or die. It's a fight we can't afford to lose and we won't. We won't!